Jun

1

Effect of ginseng components on the potassium depleted cardiomyopathic rats and it\rss mechanism of action

June 1, 2008 | Comments Off

Abstract  The effect of ginseng components on the potassium depleted cardiomyopathic rat heart was investigated. In the perfused heart
experiment using Langendorff apparatus, the deterioration rate of contractile force of potassium depleted rat heart (low potassium
diet group) was faster than that of normal rat heart and ginseng components showed the ability to slow the deterioration rate
of potassium depleted hearts. Both sialic acid contents in sarcolemmal ghost and sialyltransferase activity of 40, 000×g subcellular
fraction prepared from cardiac ventricular tissue of low potassium diet group were significantly decreased compared to those
of normal group. The decrease of the sialic acid content and sialyltransferase activity in sarcolemma of low potassium diet
group was inhibited when ginseng was concomitantly administered. Calcium uptake of sarcoplasmic reticulum prepared from low
potassium diet group was significantly greaterthan that of normal group. Ginseng extract or total saponin showed the tendency
to inhibit the increase of calcium uptake.

  • Content Type Journal Article
  • Category Orginal Articles
  • DOI 10.1007/BF02912222
  • Authors
    • Jong Wook Lee, Seoul National University College of Pharmacy 151 Seoul Korea
    • Nak Doo Kim, Seoul National University College of Pharmacy 151 Seoul Korea