May
30
Different molecular mechanisms causing 9p21 deletions in acute lymphoblastic leukemia of childhood
May 30, 2009 | Comments Off
p class=”abstract”div class=”Abstract”a name=”Abs1″/aspan class=”AbstractHeading”Abstractnbsp;nbsp;/spanDeletion of chromosome 9p21 is a crucial event for the development of several cancers including acute lymphoblastic leukemia
(ALL). Double strand breaks (DSBs) triggering 9p21 deletions in ALL have been reported to occur at a few defined sites by
illegitimate action of the V(D)J recombination activating protein complex. We have cloned 23 breakpoint junctions for a total
of 46 breakpoints in 17 childhood ALL (9 B- and 8 T-lineages) showing different size deletions at one or both homologous chromosomes
9 to investigate which particular sequences make the region susceptible to interstitial deletion. We found that half of 9p21
deletion breakpoints were mediated by ectopic V(D)J recombination mechanisms whereas the remaining half were associated to
repeated sequences, including some with potential for non-B DNA structure formation. Other mechanisms, such as microhomology-mediated
repair, that are common in other cancers, play only a very minor role in ALL. Nucleotide insertions at breakpoint junctions
and microinversions flanking the breakpoints have been detected at 20/23 and 2/23 breakpoint junctions, respectively, both
in the presence of recombination signal sequence (RSS)-like sequences and of other unspecific sequences. The majority of breakpoints
were unique except for two cases, both T-ALL, showing identical deletions. Four of the 46 breakpoints coincide with those
reported in other cases, thus confirming the presence of recurrent deletion hotspots. Among the six cases with heterozygous
9p deletions, we found that the remaining iCDKN2A/i and iCDKN2B/i alleles were hypermethylated at CpG islands.
/div/pul
lispan class=”labelName”Content Type /spanspan class=”labelValue”Journal Article/span/liliCategory Original Investigation/liliDOI 10.1007/s00439-009-0689-7/lilispan class=”labelName”Authors/spanul
liFrancesca Novara, Università degli Studi di Pavia Biologia Generale e Genetica Medica Via Forlanini, 14 27100 Pavia Italy/liliSilvana Beri, Istituto Scientifico “Eugenio Medea” Bosisio Parini Lecco Italy/liliMaria Ester Bernardo, Università degli Studi di Pavia Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo Pavia Italy/liliRiccardo Bellazzi, Università degli Studi di Pavia Dipartmento di Informatica e Sistemistica Pavia Italy/liliAlberto Malovini, Università degli Studi di Pavia Dipartmento di Informatica e Sistemistica Pavia Italy/liliRoberto Ciccone, Università degli Studi di Pavia Biologia Generale e Genetica Medica Via Forlanini, 14 27100 Pavia Italy/liliAngela Maria Cometa, Università degli Studi di Pavia Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo Pavia Italy/liliFranco Locatelli, Università degli Studi di Pavia Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo Pavia Italy/liliRoberto Giorda, Istituto Scientifico “Eugenio Medea” Bosisio Parini Lecco Italy/liliOrsetta Zuffardi, Università degli Studi di Pavia Biologia Generale e Genetica Medica Via Forlanini, 14 27100 Pavia Italy/li
/ul/li
/ulul class=”parents”
ul class=”details”
lispan class=”header labelName”Journal /spanspan class=”labelValue”a href=”http://www.springerlink.com/content/100421/”Human Genetics/a/span/lilispan class=”labelName”Online ISSN /spanspan class=”labelValue”1432-1203/span/lilispan class=”labelName”Print ISSN /spanspan class=”labelValue”0340-6717/span/li
/ul
/ul
May
30
Collision Detection for Ubiquitous Parking Management Based on Multi-agent System
May 30, 2009 | Comments Off
p class=”abstract”div class=”Abstract”Most of the researchers and designers of WSN-based parking management system used wireless sensors to detect the car presence
in automating the parking system. However, the problem of car-to-car collisions in the parking system was not discussed by
these researches where the position details of cars are important to analyze the collision event. This paper presents the
ubiquitous parking management system (UPMS) where the sensors are used to detect car presence and designed in multi-agent
system to disseminate efficiently the information through the system. The proposed system uses a location technique based
on RSS which is processed in multi-lateration method to know the position details of the cars. Also, the car active RFID (CARFID)
is equipped with vibration sensors to detect the car collision event. The system verifies the collision event in the proposed
oriented bounded box (OBB) intersection test. Experiment shows that the collision detection is more accurate if more wireless
sensors are used in our proposed technique.
/div/pul
lispan class=”labelName”Content Type /spanspan class=”labelValue”Book Chapter/span/liliDOI 10.1007/978-3-642-01665-3_57/lilispan class=”labelName”Authors/spanul
liRomeo Mark A. Mateo, Kunsan National University School of Electronic and Information Engineering 68 Miryong-dong Kunsan, Chonbuk 573-701 South Korea/liliYoung-seok Lee, Kunsan National University School of Electronic and Information Engineering 68 Miryong-dong Kunsan, Chonbuk 573-701 South Korea/liliJaewan Lee, Kunsan National University School of Electronic and Information Engineering 68 Miryong-dong Kunsan, Chonbuk 573-701 South Korea/li
/ul/li
/ulul class=”parents”
ul class=”details”
lispan class=”header labelName”Book Series /spanspan class=”labelValue”a href=”http://www.springerlink.com/content/105633/”Lecture Notes in Computer Science/a/span/lilispan class=”labelName”Online ISSN /spanspan class=”labelValue”1611-3349/span/lilispan class=”labelName”Print ISSN /spanspan class=”labelValue”0302-9743/span/li
/ulul class=”details”
lispan class=”header labelName”Book Series Volume /spanspan class=”labelValue”Volume 5559/2009/span/li
/ulul class=”details”
lispan class=”header labelName”Book /spanspan class=”labelValue”a href=”http://www.springerlink.com/content/u8m85j1r6j14/”Agent and Multi-Agent Systems: Technologies and Applications/a/span/lilispan class=”labelName”DOI /spanspan class=”labelValue”10.1007/978-3-642-01665-3/span/lilispan class=”labelName”Print ISBN /spanspan class=”labelValue”978-3-642-01664-6/span/li
/ul
/ul
May
30
Web Community Features
May 30, 2009 | Comments Off
p class=”abstract”div class=”Abstract”In the world of Web 2.0 dynamic content, a web site will sustain a broader audience if it can cultivate an active virtual
community. Fortunately, Joomla is an ideal CMS for building such a community. You have already seen some of the built-in extensions
(such as the Poll module) that can provide interactive features. In this chapter, you’ll examine other Joomla extensions that
can offer users significant opportunities to interact with your site. You’ll also learn about some of the benefits and problems
of deploying the community technologies.
/div/pul
lispan class=”labelName”Content Type /spanspan class=”labelValue”Book Chapter/span/liliDOI 10.1007/978-1-4302-1643-8_8/li
/ulul class=”parents”
ul class=”details”
lispan class=”header labelName”Book /spanspan class=”labelValue”a href=”http://www.springerlink.com/content/h81805/”Beginning Joomla!/a/span/lilispan class=”labelName”DOI /spanspan class=”labelValue”10.1007/978-1-4302-1643-8/span/lilispan class=”labelName”Online ISBN /spanspan class=”labelValue”978-1-4302-1643-8/span/lilispan class=”labelName”Print ISBN /spanspan class=”labelValue”978-1-4302-1642-1/span/li
/ul
/ul
May
30
Joomla! Extensions
May 30, 2009 | Comments Off
p class=”abstract”div class=”Abstract”One of the undeniable reasons for Joomla’s popularity is the broad spectrum of available extensions. Joomla’s celebrated extensibility
means much more than adding new templates. Through modules, components, and plug-ins, almost any type of web functionality
can be incorporated into your site.
/div/pul
lispan class=”labelName”Content Type /spanspan class=”labelValue”Book Chapter/span/liliDOI 10.1007/978-1-4302-1643-8_7/li
/ulul class=”parents”
ul class=”details”
lispan class=”header labelName”Book /spanspan class=”labelValue”a href=”http://www.springerlink.com/content/h81805/”Beginning Joomla!/a/span/lilispan class=”labelName”DOI /spanspan class=”labelValue”10.1007/978-1-4302-1643-8/span/lilispan class=”labelName”Online ISBN /spanspan class=”labelValue”978-1-4302-1643-8/span/lilispan class=”labelName”Print ISBN /spanspan class=”labelValue”978-1-4302-1642-1/span/li
/ul
/ul
May
30
Search Engine Optimization and Joomla!
May 30, 2009 | Comments Off
p class=”abstract”div class=”Abstract”No matter how much your site excels in design, implementation, and content, if web users can’t locate it, then your efforts
are largely wasted. Therefore, ensuring that your site is found by the relevant keywords on Google, Yahoo, MSN, Ask. com,
and other popular search engines is worth some effort. A well-placed link on a popular search engine can mean the difference
between popularity and anonymity.
/div/pul
lispan class=”labelName”Content Type /spanspan class=”labelValue”Book Chapter/span/liliDOI 10.1007/978-1-4302-1643-8_12/li
/ulul class=”parents”
ul class=”details”
lispan class=”header labelName”Book /spanspan class=”labelValue”a href=”http://www.springerlink.com/content/h81805/”Beginning Joomla!/a/span/lilispan class=”labelName”DOI /spanspan class=”labelValue”10.1007/978-1-4302-1643-8/span/lilispan class=”labelName”Online ISBN /spanspan class=”labelValue”978-1-4302-1643-8/span/lilispan class=”labelName”Print ISBN /spanspan class=”labelValue”978-1-4302-1642-1/span/li
/ul
/ul
May
30
Ansätze für Web 2.0-Messeportale
May 30, 2009 | Comments Off
p class=”abstract”div class=”Abstract”In Zeiten sich öffnender Märkte und globaler Vernetzung wird es für Messen immer wichtiger, sich gegenüber dem Wettbewerb
zu differenzieren und sich sowohl besucher-als auch ausstellergerichtet zu positionieren. Messen als Kommunikations—und Kontaktplattform
sowie als Berührungspunkt mit den relevanten Zielgruppen werden jedoch bislang nur temporär zum Zeitpunkt der Ausstellung
genutzt. Vor dem Hintergrund des sich immer deutlicher manifestierenden Web 2.0 und seinen interaktiven, kundenb indenden
Möglichkeiten erscheint es für Messeveranstalter angebracht, durch eine Stärkung der Online-Präsenz einen Vorsprung gegenüber
konkurrierenden Messen anzustreben bzw. diesen auszubauen. Dieser Beitragumreißt verschiedene Formen des Web 2.0 wie Blogs,
Wikis oder Weblogs und zeigt Anwendungsmöglichkeiten dieser interaktiven Kommunikationsformen zur nachhaltigen Profilierung
von Messeveranstaltern auf.
/div/pul
lispan class=”labelName”Content Type /spanspan class=”labelValue”Book Chapter/span/liliDOI 10.1007/978-3-8349-9834-7_16/lilispan class=”labelName”Authors/spanul
liGerd Robertz/li
/ul/li
/ulul class=”parents”
ul class=”details”
lispan class=”header labelName”Book /spanspan class=”labelValue”a href=”http://www.springerlink.com/content/p11543/”Aktuelle Perspektiven des Marketingmanagements/a/span/lilispan class=”labelName”DOI /spanspan class=”labelValue”10.1007/978-3-8349-9834-7/span/lilispan class=”labelName”Online ISBN /spanspan class=”labelValue”978-3-8349-9834-7/span/lilispan class=”labelName”Print ISBN /spanspan class=”labelValue”978-3-8349-1110-0/span/li
/ulul class=”details”
lispan class=”header labelName”Book Part /spanspan class=”labelValue”a href=”http://www.springerlink.com/content/p24r32512276/”Part 4/a/span/li
/ul
/ul
May
30
Cooperative Relaying in Wireless Sensor Networks
May 30, 2009 | Comments Off
p class=”abstract”div class=”Abstract”Cooperative relaying has been shown to be an effective method to significantly improve the error-rate performance in wireless
networks. This technique combats fading by exploiting the spatial diversity made available through cooperating nodes that
relay signals for each other. In the context of wireless sensor networks, cooperative relaying can be applied to reduce the
energy consumption in sensor nodes and thus extend the network lifetime. Realizing this benefit, however, requires a careful
incorporation of this technique into the routing process to exploit diversity gains. In this chapter, we introduce the basic
concepts required to understand cooperative relaying and review current state of the art energy-efficient routing protocols
that realize cooperative relaying.
/div/pul
lispan class=”labelName”Content Type /spanspan class=”labelValue”Book Chapter/span/liliDOI 10.1007/978-1-84882-218-4_6/lilispan class=”labelName”Authors/spanul
liRobin Doss, Deakin University 221 Burwood Hwy Burwood Victoria 3125 Australia/liliWolfgang Schott/li
/ul/li
/ulul class=”parents”
ul class=”details”
lispan class=”header labelName”Book Series /spanspan class=”labelValue”a href=”http://www.springerlink.com/content/x08432/”Computer Communications and Networks/a/span/lilispan class=”labelName”Print ISSN /spanspan class=”labelValue”1617-7975/span/li
/ulul class=”details”
lispan class=”header labelName”Book /spanspan class=”labelValue”a href=”http://www.springerlink.com/content/h85jn1/”Guide to Wireless Sensor Networks/a/span/lilispan class=”labelName”DOI /spanspan class=”labelValue”10.1007/978-1-84882-218-4/span/lilispan class=”labelName”Online ISBN /spanspan class=”labelValue”978-1-84882-218-4/span/lilispan class=”labelName”Print ISBN /spanspan class=”labelValue”978-1-84882-217-7/span/li
/ul
/ul
May
29
Prediction of the Period of Psychotic Episode in Individual Schizophrenics by Simulation-Data Construction Approach
May 29, 2009 | Comments Off
p class=”abstract”div class=”Abstract”a name=”Abs1″/aspan class=”AbstractHeading”Abstractnbsp;nbsp;/spanAlthough schizophrenia can be treated, most patients still experience inevitable psychotic episodes from time to time. Precautious
actions can be taken if the next onset can be predicted. However, sufficient information is always lacking in the clinical
scenario. A possible solution is to use the virtual data generated from limited of original data. Data construction method
(DCM) has been shown to generate the virtual felt earthquake data effectively and used in the prediction of further events.
Here we investigated the performance of DCM in deriving the membership functions and discrete-event simulations (DES) in predicting
the period embracing the initiation and termination time-points of the next psychotic episode of 35 individual schizophrenic
patients. The results showed that 21 subjects had a success of simulations (RSS) ≥70%. Further analysis demonstrated that
the co-morbidity of coronary heart diseases (CHD), risks of CHD, and the frequency of previous psychotic episodes increased
the RSS. (150 words)
/div/pul
lispan class=”labelName”Content Type /spanspan class=”labelValue”Journal Article/span/liliCategory Original Paper/liliDOI 10.1007/s10916-009-9294-5/lilispan class=”labelName”Authors/spanul
liChun-Jung Huang, National Tsing-Hua University Department of Industrial Engineering and Engineering Management, College of Engineering HsinChu Taiwan/liliHsiao-Fan Wang, National Tsing-Hua University Department of Industrial Engineering and Engineering Management, College of Engineering HsinChu Taiwan/liliHsien-Jane Chiu, Department of Health Jianan Mental Hospital Tainan County Taiwan/liliTsuo-Hung Lan, National Health Research Institutes Division of Mental Health and Substance Abuse Research, Institute of Population Health Sciences 35 Keyan Road Zhunan Miaoli County 350 Taiwan/liliTsung-Ming Hu, Yu-Li Veterans Hospital Yu-Li Town Hualian County Taiwan/liliEl-Wui Loh, National Health Research Institutes Division of Mental Health and Substance Abuse Research, Institute of Population Health Sciences 35 Keyan Road Zhunan Miaoli County 350 Taiwan/li
/ul/li
/ulul class=”parents”
ul class=”details”
lispan class=”header labelName”Journal /spanspan class=”labelValue”a href=”http://www.springerlink.com/content/104921/”Journal of Medical Systems/a/span/lilispan class=”labelName”Online ISSN /spanspan class=”labelValue”1573-689X/span/lilispan class=”labelName”Print ISSN /spanspan class=”labelValue”0148-5598/span/li
/ul
/ul
May
29
GMO Strawberry: Methods, Risk and Benefits
May 29, 2009 | Comments Off
p class=”abstract”div class=”Abstract”The potential for profitable applications of biotechnology to many fruits and vegetables, tree fruits and nuts, can be limited
by the high cost of research, development and regulatory approval combined with the small plantations and the diversity of
varieties. Further, experimentation with perennials such as fruit trees, berry and nuts and is comparatively expensive (because
the experimental unit is larger and takes more time), and it is costly and not easy to bring into new plantations or replacing
and existing orchards with a new variety. For these reasons biotech application in horticultural crops are quite limited at
research level and commercialization is almost completely absent. Horticultural crops use much less land but their production
is of much higher value. Upon this situation, the development of biotechnology applications in horticultural crops and the
achievement of market acceptance can be expected, in the near future, mainly for those crops with a broader importance in
cultivation and market.
/div/pul
lispan class=”labelName”Content Type /spanspan class=”labelValue”Book Chapter/span/liliDOI 10.1007/978-0-387-77491-6_23/lilispan class=”labelName”Authors/spanul
liBruno Mezzetti, Dipartimento di Scienze Ambientali e delle Produzioni Vegetali – Marche Polytechnic University Ancona IT Italy/li
/ul/li
/ulul class=”parents”
ul class=”details”
lispan class=”header labelName”Book Series /spanspan class=”labelValue”a href=”http://www.springerlink.com/content/l43456/”Plant Genetics and Genomics: Crops and Models/a/span/li
/ulul class=”details”
lispan class=”header labelName”Book Series Volume /spanspan class=”labelValue”Volume 6/span/li
/ulul class=”details”
lispan class=”header labelName”Book /spanspan class=”labelValue”a href=”http://www.springerlink.com/content/q82288/”Genetics and Genomics of Rosaceae/a/span/lilispan class=”labelName”DOI /spanspan class=”labelValue”10.1007/978-0-387-77491-6/span/lilispan class=”labelName”Online ISBN /spanspan class=”labelValue”978-0-387-77491-6/span/lilispan class=”labelName”Print ISBN /spanspan class=”labelValue”978-0-387-77490-9/span/li
/ulul class=”details”
lispan class=”header labelName”Book Part /spanspan class=”labelValue”a href=”http://www.springerlink.com/content/r2741hk5505t/”Part IV/a/span/li
/ul
/ul
May
29
Towards “Stakeholder University” as dynamic learning network: the Finmeccanica case
May 29, 2009 | Comments Off
p class=”abstract”div class=”Abstract”Over the past 10 years, a radical transformation processes is at work, in terms of converging industry boundaries and change
rates in global-scale markets and industries, and increasing customer influence (Ghoshal and Bartlett 1997; Cusumano 2001).
div class=”AbstractPara”
div class=”"The main forces that have determined this transformation process may be identified in (Marquardt 2002; Baets and Linden 2003)/div
/div
/div/pul
lispan class=”labelName”Content Type /spanspan class=”labelValue”Book Chapter/span/liliDOI 10.1007/978-1-4419-0251-1_6/lilispan class=”labelName”Authors/spanul
liRoberto Maglione, Finmeccanica Group Executive Vice President Human Resources Piazza Monte Grappa 4 – 00195 Roma IT/liliGiuseppina Passiante, University of Salento, Campus Ecotekne Full Professor eBMS, Scuola Superiore ISUFI Via per Monteroni 73100 Lecce/li
/ul/li
/ulul class=”parents”
ul class=”details”
lispan class=”header labelName”Book /spanspan class=”labelValue”a href=”http://www.springerlink.com/content/mv80t7/”Dynamic Learning Networks/a/span/lilispan class=”labelName”DOI /spanspan class=”labelValue”10.1007/978-1-4419-0251-1/span/lilispan class=”labelName”Online ISBN /spanspan class=”labelValue”978-1-4419-0251-1/span/lilispan class=”labelName”Print ISBN /spanspan class=”labelValue”978-1-4419-0250-4/span/li
/ul
/ul